Founded as a precious metals company in South Africa, Argen has evolved into a dynamic, technology-based manufacturing organization focused on three key business segments, including dental alloys, zirconia, and digital dentistry solutions. If you are passionate about sourcing and securing highly qualified talent at all levels of the organization, thrive in a fast- paced and dynamic environment, and want to be a part of an organization with an unwavering commitment to quality dental solutions, then explore our career opportunities and get to know Argen.Īrgen is a family-owned and privately held company based in San Diego, CA with a state-of-the-art manufacturing center that provides high quality dental solutions to dental labs of all sizes. above or below their isoelectric point.Argen Corporation currently has an exciting opportunity for a Human Resources Manager to join a growing, technology-focused and service-oriented team. Formulation development teams can use kinetic data collected by ARGEN to see differences in AR within solutions containing surface charged and surface neutral proteins, i.e. This application note summarizes the use of ARGEN to determine colloidal stability for Bovine Serum Albumin (BSA) at three different solution pH levels. The aggregation or degradation rate offers a valuable and accurate measurement for colloidal stability for protein formulations and polymer solutions. Furthermore, since all data is generated continuously and in real time, ARGEN analysis methods can determine the kinetic Aggregation Rate (AR) for each sample independently. This enables them to identify the onset of aggregation, degradation, or a phase change more rapidly than with other technologies. Researchers using ARGEN can quickly detect changes in the relative molecular weight for molecules in solution. This allows the benefit of expediting formulation exploration and development. Testing each sample independently allows for control and rapid characterization of multiple stress conditions in each study. Additionally, ARGEN users can introduce and remove samples from testing without affecting other ongoing measurements. Because most therapeutic protein formulations are difficult and expensive to produce at high yields, biopharma companies need tools that provide rapid, high quality protein stability information with low sample consumption.ĪRGEN is a light scattering instrument with 16 independent sample cells that allow multiple, independent experiments, each one with its own stress conditions. For each therapeutic, biopharma companies use formulation development to search for the unique “goldilocks zone” where the solution is stable in all the required conditions. This trade space includes factors such as solvent choice, ionic strength, pH, concentration and excipients. To mitigate against protein degradation, drug companies employ formulation development.Ī formulation is one solution condition in a multidimensional therapeutic trade space. The challenge for biopharmaceutical companies is that degraded proteins create ineffective and potentially harmful therapeutics for their customers. Unstable proteins are more prone to degradation from the primary stress mechanisms: mechanical and thermal (from manufacturing, storage and transport) and biological (from drug delivery). Unfortunately, when removed from their native environments, proteins become less stable. Biopharmaceutical companies isolate many types of proteins for use in experimental and therapeutic medicines.
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